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|Title:||Is selective decontamination (SDD/SOD) safe in the ICU context?|
|Author:||Hurley, James C.|
|Publication Title:||Journal of Antimicrobial Chemotherapy|
|Abstract:||Multiple individual studies of selective digestive decontamination/selective oropharyngeal decontamination (SDD/SOD) among ICU patients appear to show potent infection prevention effects. Surprisingly, the event rates for multiple endpoints including ventilator-associated pneumonia, bacteraemia and candidaemia among concurrent control groups within SDD/SOD studies appear unusually high versus other rates in the literature. These paradoxical observations raise concern that the contextual effects of SDD/SOD, as postulated in the original SDD/SOD study, not only exist but also are strong. Until these effects are addressed within an optimally designed study, the safety of SDD/SOD within the ‘whole of ICU’ remains questionable.|
|Internal ID Number:||01355|
|Health Subject:||SELECTIVE DIGESTIVE DECONTAMINATION|
SELECTIVE OROPHARYNGEAL DECONTAMINATION
|Appears in Collections:||Research Output|
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