Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1209
Title: Unusually high incidences of Staphylococcus aureus Infection within studies of ventilator associated pneumonia prevention using topical antibiotics: benchmarking the evidence base.
Author: Hurley, James C.
Issue Date: 2018
Publication Title: Microoorganisms
Volume: 6
Issue: 1
Start Page: 2
Abstract: Selective digestive decontamination (SDD, topical antibiotic regimens applied to the respiratory tract) appears effective for preventing ventilator associated pneumonia (VAP) in intensive care unit (ICU) patients. However, potential contextual effects of SDD on Staphylococcus aureus infections in the ICU remain unclear. The S. aureus ventilator associated pneumonia (S. aureus VAP), VAP overall and S. aureus bacteremia incidences within component (control and intervention) groups within 27 SDD studies were benchmarked against 115 observational groups. Component groups from 66 studies of various interventions other than SDD provided additional points of reference. In 27 SDD study control groups, the mean S. aureus VAP incidence is 9.6% (95% CI; 6.9–13.2) versus a benchmark derived from 115 observational groups being 4.8% (95% CI; 4.2–5.6). In nine SDD study control groups the mean S. aureus bacteremia incidence is 3.8% (95% CI; 2.1–5.7) versus a benchmark derived from 10 observational groups being 2.1% (95% CI; 1.1–4.1). The incidences of S. aureus VAP and S. aureus bacteremia within the control groups of SDD studies are each higher than literature derived benchmarks. Paradoxically, within the SDD intervention groups, the incidences of both S. aureus VAP and VAP overall are more similar to the benchmarks.
URI: http://hdl.handle.net/11054/1209
ISSN: 2076-2067
DOI: https://doi.org/10.3390/microorganisms6010002
Internal ID Number: 01135
Health Subject: VENTILATOR ASSOCIATED PNEUMONIA
STAPHYLOCOCCUS AUREUS
ANTIBIOTIC PROPHYLAXIS
STUDY DESIGN
INTENSIVE CARE
MECHANICAL VENTILATION
CROSS INFECTION
NOSOCOMIAL INFECTION
SELECTIVE DIGESTIVE CONTAMINATION
ANTIBIOTICS
BENCHMARKING
Type: Journal Article
Article
Appears in Collections:Research Output

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