Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1124
Title: Pharmacoeconomic evaluation of micafungin versus caspofungin as definitive therapy for candidaemia and invasive candidiasis (IC) in Turkey.
Author: Neoh, C. F.
Senol, E.
Kara, A.
Dinleyici, E. C.
Turner, S. J.
Kong, David C.M.
Issue Date: 2018
Publication Title: European Journal of Clinical Microbiology & Infectious Diseases
Volume: 37
Issue: 3
Start Page: 537
End Page: 544
Abstract: Micafungin was shown to be as efficacious as caspofungin in treating patients with candidaemia and invasive candidiasis (IC). However, it remains unknown if micafungin or caspofungin is a cost-effective definitive therapy for candidaemia and IC in Turkey. The present study aimed to determine the economic impact of using micafungin versus caspofungin for treatment of candidaemia and IC in the Turkish setting. A decision analytic model was constructed and was populated with data (i.e. transition probabilities, duration of initial antifungal treatment, reasons for treatment failure, percentage of patients who stepped down to oral fluconazole, and duration on oral fluconazole) obtained from a published randomised clinical trial. Cost inputs were derived from the latest Turkish resources while data that were not readily available in the literature were estimated by expert panels. One-way sensitivity analyses, threshold analyses, scenario analyses and probabilistic sensitivity analyses were conducted. Caspofungin (€2693) incurred a lower total cost than micafungin (€4422), with a net cost saving of €1729 per treated patient. Drug acquisition cost was the main cost driver for both study arms. The model outcome was robust over wide variations (of ±100.0% from the base case value) for all input parameters except for micafungin drug cost and the duration of initial treatment with micafungin. Caspofungin appears to be a cost-saving option in treating candidaemia and IC from the Turkish hospital perspective.
URI: http://hdl.handle.net/11054/1124
ISSN: 0722-2211
DOI: 10.1007/s10096-017-3147-9
Internal ID Number: 01102
Health Subject: ANTIFUNGAL AGENTS
MICAFUNGIN
CASPOFUNGIN
FLUCONAZOLE
CANDIDA
CANDIDEMIA
CANDIDIASIS, INVASIVE
DRUG COSTS
COST SAVINGS
COST-BENEFIT ANALYSIS
MODELLING
TURKEY
Type: Journal Article
Article
Appears in Collections:Research Output

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