Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/1115
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dc.contributorPeñuelas, Oscaren_US
dc.contributorAlfonso, Murielen_US
dc.contributorFrutos-Vivar, Fernandoen_US
dc.contributorFan, Eddyen_US
dc.contributorRaymondos, Konstantinosen_US
dc.contributorRios, Fernandoen_US
dc.contributorNin, Nicolásen_US
dc.contributorThille, Arnaud W.en_US
dc.contributorGonzalez, Marcoen_US
dc.contributorVillagomez, Asisclo J.en_US
dc.contributorDavies, Andrew R.en_US
dc.contributorDu, Binen_US
dc.contributorMaggiore, Salvatore M.en_US
dc.contributorMatamis, Dimitriosen_US
dc.contributorAbroug, Fekrien_US
dc.contributorMoreno, Rui P.en_US
dc.contributorKuiper, Michael A.en_US
dc.contributorAnzueto, Antonioen_US
dc.contributorFerguson, Niall D.en_US
dc.contributorEsteban, Andrésen_US
dc.date.accessioned2018-02-27T03:10:11Z-
dc.date.available2018-02-27T03:10:11Z-
dc.date.issued2018-
dc.identifier.govdoc01023en_US
dc.identifier.issn0885-0666en_US
dc.identifier.urihttp://hdl.handle.net/11054/1115-
dc.description.abstractTony Sutherland and Dianne Hill from Ballarat Health Services, Ballarat are listed under Australia in the Third International Study on Mechanical Ventilation Investigators list (Authors Note: p. 7-8) BACKGROUND: Intensive care unit-acquired paresis (ICUAP) is associated with poor outcomes. Our objective was to evaluate predictors for ICUAP and the short-term outcomes associated with this condition. METHODS: A secondary analysis of a prospective study including 4157 mechanically ventilated adults in 494 intensive care units from 39 countries. After sedative interruption, patients were screened for ICUAP daily, which was defined as the presence of symmetric and flaccid quadriparesis associated with decreased or absent deep tendon reflexes. A multinomial logistic regression was used to create a predictive model for ICUAP. Propensity score matching was used to estimate the relationship between ICUAP and short-term outcomes (ie, weaning failure and intensive care unit [ICU] mortality). RESULTS: Overall, 114 (3%) patients had ICUAP. Variables associated with ICUAP were duration of mechanical ventilation (relative risk ratio [RRR] per day, 1.10; 95% confidence interval [CI] 1.08-1.12), steroid therapy (RRR 1.8; 95% CI, 1.2-2.8), insulin therapy (RRR 1.8; 95% CI 1.2-2.7), sepsis (RRR 1.9; 95% CI: 1.2 to 2.9), acute renal failure (RRR 2.2; 95% CI 1.5-3.3), and hematological failure (RRR 1.9; 95% CI: 1.2-2.9). Coefficients were used to generate a weighted scoring system to predict ICUAP. ICUAP was significantly associated with both weaning failure (paired rate difference of 22.1%; 95% CI 9.8-31.6%) and ICU mortality (paired rate difference 10.5%; 95% CI 0.1-24.0%). CONCLUSIONS: Intensive care unit-acquired paresis is relatively uncommon but is significantly associated with weaning failure and ICU mortality. We constructed a weighted scoring system, with good discrimination, to predict ICUAP in mechanically ventilated patients at the time of awakening.en_US
dc.description.provenanceSubmitted by Gemma Siemensma (gemmas@bhs.org.au) on 2018-02-27T02:12:47Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Gemma Siemensma (gemmas@bhs.org.au) on 2018-02-27T03:10:10Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2018-02-27T03:10:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.titlePrediction and outcome of intensive care unit-acquired paresis.en_US
dc.typeJournal Articleen_US
dc.type.specifiedArticleen_US
dc.bibliographicCitation.titleJournal of Intensive Care Medicineen_US
dc.bibliographicCitation.volume33en_US
dc.bibliographicCitation.issue1en_US
dc.bibliographicCitation.stpage16en_US
dc.bibliographicCitation.endpage28en_US
dc.subject.healththesaurusRESPIRATION, ARTIFICIALen_US
dc.subject.healththesaurusICUen_US
dc.subject.healththesaurusINTENSIVE CARE UNITSen_US
dc.subject.healththesaurusINTENSIVE CARE STATISTICS & NUMERICAL DATAen_US
dc.subject.healththesaurusPARESISen_US
dc.subject.healththesaurusPROSPECTIVE STUDIESen_US
dc.identifier.doi10.1177/0885066616643529en_US
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