Please use this identifier to cite or link to this item: http://hdl.handle.net/11054/11
Title: Antibiotic-induced release of endotoxin: a therapeutic paradox.
Authors: Hurley, James C.
Issue Date: 1995
Publisher: ADIS Press Limited
Place of publication: Auckland
Journal title: Drug safety
Volume: 12
Issue: 3
Start Page: 183
End Page: 195
Abstract: There is clear experimental evidence that antibiotics increase the bioavailability of endotoxin from Gram-negative bacteria. In this review, data for 2 variables, level of endotoxin and level of bacteria, at the time point closest to 2 hours post-antibiotic exposure were abstracted as a change from baseline readings from each available study, to enable presentation in a graphical overview. This overview indicates that the phenomenon is not limited to beta-lactam agents nor is it apparent only for the more rapidly bactericidal agents. However, evidence that this phenomenon is of clinical importance is scant. With the Jarisch-Herxheimer reaction (JHR), there is clear evidence for an acute deterioration with the initiation of antibiotic therapy and yet uncertainty as to the nature of the bacterial mediator(s) of this reaction. There is no evidence to support the commonly stated concern that therapy with antibiotics with a more rapid bactericidal action may result in the sudden lysis of bacteria with the release of cell wall components and cause a deterioration that might be avoidable through the use of antibiotics with a slower time course of action.
URI: http://hdl.handle.net/11054/11
ISSN: 0114-5916
Internal ID Number: 00003
Health Subject: ANTI-BACTERIAL AGENTS
ADVERSE EFFECTS
ENDOTOXINS
ENDOTOXIN SECRETION
ANTI-BACTERIAL AGENTS
SEPSIS
DRUG THERAPY
MICROBIOLOGY
GRAM NEGATIVE BACTERIA
METABOLISM
Type: Journal Article
Article
Appears in Collections:Research Output

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